https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55725 Wed 19 Jun 2024 09:40:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51034 Wed 16 Aug 2023 10:16:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39851 .05). Objective sleep onset latency increased from the Baseline to the Treatment phase in the control (stretching) group (p = .042). In contrast, the Cycling group exhibited improvements in sleep duration (p = .008) and sleep efficiency (p = .023) during the Treatment phase compared to the Baseline phase. Cycling also increased sleep duration (p = .005), decreased average wake bout (p = .040) and tended to increase sleep efficiency (p = .051) compared to stretching during the Treatment phase. Subjective sleep quality ratings did not differ between groups (p > .10). These preliminary findings suggest that moderate-intensity aerobic exercise may attenuate the sleep disturbances associated with cannabis withdrawal.]]> Tue 26 Jul 2022 09:52:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35731 in-vivo, including in animals with cocaine experience. First, we verified that group III mGluRs regulate orexin cell activity in behaving animals by showing that intra-LHA infusions of the selective agonist L-(+)-2-Amino-4-phosphonobutyric acid (L-AP4) reduces c-fos expression in orexin cells following 24 h food deprivation. Next, we extended these findings to show that intra-LHA L-AP4 infusions reduced discriminative stimulus-driven cocaine-seeking following withdrawal. Importantly, L-AP4 had no effect on lever pressing for sucrose pellets or general motoric behavior. Finally, using whole-cell patch-clamp recordings from identified orexin cells in orexin-GFP transgenic mice, we show enhanced presynaptic drive to orexin cells following 14d withdrawal and that this plasticity can be normalized by L-AP4. Together, these data indicate that activation of group III mGluRs in LHA reduces orexin cell activity in vivo and may be an effective strategy to suppress cocaine-seeking behavior following withdrawal. These effects are likely mediated, at least in part, by normalization of presynaptic plasticity at orexin cells that occurs as a result of cocaine exposure. This article is part of the Special Issue entitled ‘Hypothalamic Control of Homeostasis’.]]> Thu 28 Oct 2021 13:02:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52634 Thu 19 Oct 2023 15:11:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6684 Sat 24 Mar 2018 07:46:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30941 Sat 24 Mar 2018 07:33:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28421 Sat 24 Mar 2018 07:29:05 AEDT ]]>